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Industrial Process For Oxiconazole Dr Krishnasarma Pathy Step-i 2,2’4’-tri-choloroacetophenone,imidazole Reacted In Presence Of Acetonitrile To Form 1-(2,4-dichlorophenacyl)-imidazole (i).which Is Then Reacted With Hydroxylamine. Hydrochloride To Give (z)-1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl) Ethanone Oxime (ii). It Is Further Reacted With 2,4-dichlorobenzyl Chloride In Presence Of Sodium Hydride To Give (iii) Oxiconazole And Finally Salt Formation With Nitric Acid
Description: Oxiconazole inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol...
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