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Multicomponent Reactions with Isocyanides - Alexander Domling Ivar Ugi - Angew Chem Int Ed, 2000, 39(18), 3168-3210 - PII 1433-7851(00)3918-3169 DOI: 10.1002/1521-3773(20000915)39:183.0.CO;2-U Angewandte Chemie International Edition Volume 39, Issue 18, pages 3168–3210, September 15, 2000 Dömling, A. and Ugi, I. (2000), Multicomponent Reactions with Isocyanides. Angew. Chem. Int. Ed., 39: 3168–3210 Author Information 1Morphochem AG Gmunderstrasse 37–37 a, 81379 München (Germany) Fax: (+49) 89-78005-555 2 Institut für Organische Chemie und Biochemie Technische Universität München 85747 Garching (Germany) Email: Alexander Dömling Dr. (
[email protected]) ABSTRACT: Multicomponent reactions (MCRs) are fundamentally different from two-component reactions in several aspects. Among the MCRs, those with isocyanides have developed into popular organic-chemical reactions in the pharmaceutical industry for the preparation of compound libraries of low-molecular druglike compounds. With a small set of starting materials, very large libraries can be built up within a short time, which can then be used for research on medicinal substances. Due to the intensive research of the last few years, many new backbone types have become accessible. MCRs are also increasingly being employed in the total synthesis of natural products. MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures. However, this requires that the chemist learns the “language” of MCRs, something that this review wishes to stimulate. KEYWORDS: organic chemistry, medicinal chemistry, science, Ugi reaction, opioids, opiates, narcotic analgesic, fentanyl, carfentanil, remifentanil, mu opioid recptor agonist, combinatorial chemistry, isocyanides, multicomponent reactions, organic synthesis, isonitriles, total synthesis, natural product chemistry, chemical reactions, drug synthesis, drug manufacture, drug chemistry, synthetic methods
