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Schnitzler Syndrome and IgM . Author Prof. Hayk S. Arakelyan. Full Professor in Medicine, Doctor of Medical Sciences, Ph.D , Grand Ph.D . Senior Expert of Interactive Clinical Pharmacology , Drug Safety, Treatment Tactics, General Medicine and Clinical Research. “ Do not give in too much to feelings. A overly sensitive heart is an unhappy possession on this shaky earth. ” “ Johann Wolfgang von Goethe ” Introduction. The disease is named after the French dermatologist Liliane Schnitzler who first described this syndrome in 1972. Schnitzler syndrome is characterized by chronic, nonpruritic urticaria in association with recurrent fever, bone pain, arthralgia or arthritis, and a monoclonal gammopathy, most often of the immunoglobulin M (IgM) subtype . Approximately 10-15% of patients eventually develop a lymphoproliferative disorder , such as lymphoplasmacytic lymphoma, Waldenström macroglobulinemia, or IgM myeloma. Signs and symptoms. Schnitzler syndrome is characterized by the following signs and symptoms: recurrent hives, mostly on the torso and limbs, often with recurring fever, joint pain, bone pain, muscle pain, headache, fatigue, and loss of weight. Diagnosis. Immunoglobulin M (IgM) or rarely IgG monoclonal gammopathy: Detected with serum immunoelectrophoresis; occurs in all patients; in 51% of cases, however, serum protein electrophoresis may not detect it. Blood tests show a high concentration of specific gamma-globulins (monoclonal gammopathy) of the IgM type . It almost always has light chains of the κ -type. A variant in which IgG is raised has been described, which appears to be one-tenth as common . The immunoglobulins may show up in the urine as Bence Jones proteins. Signs of inflammation are often present: these include an increased white blood cell count (leukocytosis) and a raised erythrocyte sedimentation rate and C-reactive protein. There can be anemia of chronic disease. Abnormal lymphoid proliferation : 20% of bone marrow biopsy samples, with nonspecific polyclonal lymphocytic and plasmacytic infiltrates . - Management and Treatment Perspectives. - Autoimmunisation and Schnizler Syndrome. - Pathophysiology. - Epidemiology. - IgM, IGG and Schnizler Syndrome. - IgM, IGG and other Diseases. - IgM and IgG class antibodies and Allergy Types. To be continued .... If you have any questions concerning “ Schnitzler Syndrome and IgM .” , interactive clinical pharmacology , or any other questions, please inform me . Prof. Hayk S. Arakelyan
